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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 44 kDa
物種活性
human, rat
濃度
~1 mg/mL
技術
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
proteolytically cleaved (Asp369)
基因資訊
human ... ACAN(176)
一般說明
抗-聚集蛋白聚糖(裂解-Val369)抗体可检测激活聚集蛋白聚糖(裂解-Val369)蛋白片段的内源性水平。
聚集蛋白聚糖是人软骨的大聚集硫酸软骨素蛋白聚糖。它由AGC1(聚集蛋白聚糖)基因编码。它定位于人类染色体15q26.1。
免疫原
该抗血清是针对衍生自人聚集蛋白聚糖的合成肽而生成的。
免疫原范围: 320-369
免疫原范围: 320-369
應用
N端抗聚集蛋白聚糖(裂解的Asp369)抗体已用于蛋白质印迹和免疫染色。
生化/生理作用
聚集蛋白聚糖的突变会导致常染色体显性遗传的矮小身材,并加速骨骼成熟。聚集蛋白聚糖基因(AGC1)的可变重复区域中的突变导致脊椎骨发育异常。
特點和優勢
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。
外觀
兔IgG,溶于磷酸盐缓冲液(不含Mg2+和Ca2+),pH 7.4,150mM NaCl,0.02%叠氮化钠和50%甘油中。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
nwg
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Gene expression profiles of early chondrogenic markers in dedifferentiated fat cells stimulated by bone morphogenetic protein 4 under monolayer and spheroid culture conditions in vitro
Orthodontic Waves, 75(4), 97-104 (2016)
Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations.
The Journal of Clinical Endocrinology and Metabolism, 102(2), 460-469 (2017)
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
The Journal of Biological Chemistry, 266(2), 894-902 (1991)
Cell stress & chaperones, 21(1), 97-104 (2015-09-20)
Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its activation is associated with endplate chondrocyte apoptosis. However, the precise role
International journal of molecular medicine, 41(2), 977-984 (2017-12-06)
Despite various animal serums being used widely to culture chondrocytes, the regulatory mechanism of serum on chondrocyte activities has not been elucidated. In the present study, human osteoarthritis (OA) chondrocytes were used to perform in vitro investigations on the effect of
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