生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 56 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TXNRD2(10587)
一般說明
Anti-TRXR2 Antibody detects endogenous levels of total TRXR2 protein.
Thioredoxin reductase 2 (TRXR2) is mitochondrial protein-disulfide oxidoreductase, encoded by the gene mapped to human chromosome 22q11.21. TRXR2 is one of the mammalian isoforms of thioredoxin reductase (TrxR).
免疫原
The antiserum was produced against synthesized peptide derived from human TRXR2.
Immunogen Range: 471-520
Immunogen Range: 471-520
生化／生理作用
Thioredoxin reductase 2 (TRXR2) regulates cell survival during mammalian embryonic development. In addition, it also regulates mitochondria-dependent apoptosis. TRXR2 also controls protein tyrosine phosphorylation and cell proliferation. The protein expression is associated with development of glioma. In humans, this enzyme stimulates the apoptosis in HeLa cells. Mutation in the gene might increase the risk of susceptibility to myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) patients.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The Genes Associated with RNA Editing and Glioma on the Chromosome 22q.
Wang G and Tian Y
Advances in Medical Sciences, 2(1) (2014)
Mitochondrial thioredoxin system effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis.
Patenaude A, et al.
The Journal of Biological Chemistry, 279(26), 27302-27314 (2004)
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Kariz S, et al.
Diabetes Research and Clinical Practice, 108(2), 323-328 (2015)
Involvements of mitochondrial thioredoxin reductase (TrxR2) in cell proliferation
Kim MR, et al.
Biochemical and Biophysical Research Communications, 304(1), 119-124 (2003)
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