SAB4300032
抗 磷酸化-STAT1 (pTyr 701 ) 兔抗
affinity isolated antibody
别名:
Anti-DKFZp686B04100 antibody produced in rabbit, Anti-ISGF-3 antibody produced in rabbit, Anti-STAT91 antibody produced in rabbit, Anti-signal transducer and activator of transcription 1, 91kDa antibody produced in rabbit
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About This Item
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~91 kDa
物種活性
human, mouse
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(T-G-YP-I-K)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pTyr701)
基因資訊
human ... STAT1(6772)
一般說明
Signal transducer and activator of transcription 1 (STAT1) gene is mapped to human chromosome 2q32.2. It is part of the STAT family of proteins. STAT1 exists in two isoforms, STAT1α and STAT1β with molecular weight of 91kDa and 84kDa, respectively. The protein shows ubiquitous expression.
免疫原
Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K), according to the protein STAT1.
生化／生理作用
Signal transducer and activator of transcription 1 (STAT1) plays a vital role in interferon (IFN) signaling. Phospho-STAT1 regulates pro- and anti-apoptotic genes following several stress-induced responses. It interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT1 is also an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumor suppressor.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
Yamamoto K
Cytogenetics and Cell Genetics (1997)
STAT-1: a novel regulator of apoptosis.
Stephanou A and Latchman DS
International Journal of Experimental Pathology (2003)
Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.
Faseb Journal (2004)
Assignment1 of STAT1 to human chromosome 2q32 by FISH and radiation hybrids.
Haddad B
Cytogenetics and Cell Genetics (1998)
Brigid M O'Flaherty et al.
PLoS pathogens, 10(8), e1004302-e1004302 (2014-08-08)
MHV68 is a murine gammaherpesvirus that infects laboratory mice and thus provides a tractable small animal model for characterizing critical aspects of gammaherpesvirus pathogenesis. Having evolved with their natural host, herpesviruses encode numerous gene products that are involved in modulating
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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