推荐产品
生物源
mouse
品質等級
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
HP-6014, monoclonal
形狀
buffered aqueous solution
物種活性
human
濃度
~1.0 mg/mL
技術
immunofluorescence: suitable
indirect ELISA: 0.07-0.15 μg/mL using 1 μg/mL Human IgG2 myeloma for coating
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
Anti-Human IgG2 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the HP-6014 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgG2 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads. Human IgG consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5, and 4% of the total IgG, respectively.
免疫原
Purified human IgG2 myeloma protein
應用
Anti-Human IgG2 antibody, Mouse monoclonal may be used in immunological techniques, including enzyme linked immunosorbent assay (ELISA), immunofluorescence, hemagglutination (HA) and hemagglutination inhibition.
生化／生理作用
Lipopolysaccharides stimulate an IgG2 response in peripheral blood leukocytes (PBL) and an IgG1 response in the spleen. Only IgG1 and IgG3 are capable of adherence to mononuclear phagocytes while IgG2 and IgG4 autoantibodies are much less efficient. The amount of the different IgG subclasses present in the blood shows variation with age. For example, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels raise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. For example, IgG2 and IgG4 deficiency is found in patients of ataxia telangiectasia. Low IgG2 levels were found in patients with Systemic lupus erythematosus (SLE) and juvenile diabetes mellitus.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood
Blanco E, et al.
The Journal of Allergy and Clinical Immunology, 141(6), 2208-2219 (2018)
Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy
Scott-Taylor TH, et al.
Immunity, inflammation and disease, 6, 13-33 (2018)
V A Oxelius et al.
Clinical and experimental immunology, 99(2), 211-215 (1995-02-01)
IgA deficiency (IgAD) is the most common immunodeficiency, characterized by an arrest in B cell differentiation. It has a sporadic occurrence or variable inheritance pattern, and is also linked to the HLA genes. IgA deficiency is sometimes associated with IgG
Effect of anti-epileptic drugs on serum level of IgG subclasses
Ashrafi MR, et al.
Iranian journal of pediatrics, 20(3), 269-269 (2010)
Immunodeficiency and infections in ataxia-telangiectasia
Nowak-Wegrzyn A, et al.
The Journal of Pediatrics, 144(4), 505-511 (2004)
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