推荐产品
生物源
mouse
品質等級
共軛
peroxidase conjugate
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
GE-1, monoclonal
形狀
lyophilized powder
物種活性
human
技術
ELISA: 1:20,000-1:30,000 using 5 μg/mL Human IgE myeloma for coating
同型
IgG2b
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
Monoclonal Anti-Human IgE (mouse IgG2b isotype) is derived from the GE-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgE myeloma protein. IgE (Immunoglobulin E) is the least abundant immunoglobulin isotype. IgE is produced by plasma cells and is highly functional in the lung, skin, and mucous membranes. Normal levels of IgE in serum are less than 1 μmL.
特異性
Monoclonal Anti-Human IgE specifically recognizes Human IgE. The antibody shows no cross-reactivity with human IgG1, IgG2, IgG3, IgG4, IgA, and IgM.
免疫原
Purified human IgE
應用
Anti-Human IgE-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).
生化／生理作用
IgE plays a critical role in allergic reactions and host protection from parasites. During an allergic reaction such as atopic eczema, extrinsic asthma or hay fever, fungal and parasitic infection, atopic disease, or primary immunodeficiency the serum IgE levels can be induced up to 5-fold. IgE specifically and reversibly binds to the membrane receptor Fc-epsilon receptors (FcεR) type I on the surface of basophils, eosinophils, and mast cells. This binding activates the release of histamine, leukotrienes, and other mediators responsible for hypersensitivity. The recognition and isolation of allergen-specific IgE can lead to progress in understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders.
外觀
Supplied as a lyophilized powder.
其他說明
This product is for R&D use only, not for drug, household, or other uses.
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訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
IgE and mast cells in allergic disease
Galli S J and Tsai M
Nature Medicine, 18(5), 693-693 (2012)
IgE and mast cells in allergic disease
Wachholz P A, et al.
Journal of Immunotoxicology, 1(3-4), 189-199 (2005)
R H Buckley et al.
The Journal of clinical investigation, 55(1), 157-165 (1975-01-01)
Concentrations of IgD and IgE were measured in sera from 165 patients with well-defined immunodeficiency in an effort to find information possibly relevant to the roles of antibodies of these classes in host defense. Values for both immunoglobulins were generally
F Zellweger et al.
Allergy, 71(12), 1652-1661 (2016-10-07)
IgE-associated allergic diseases belong to the most common inflammatory conditions. Their clinical manifestation ranges from mild symptoms to life-threatening episodes. Often patients experience a reduction in physical and psychologic well-being and suffer from a decreased quality of life due to
T J Suutari et al.
Journal of investigational allergology & clinical immunology, 16(5), 296-302 (2006-10-17)
Allergic reactions to cow's milk are common in small children. One of the main protein allergens found in cow's milk is beta-lactoglobulin (beta-Lg). Reindeer and bovine milk both contain related beta-Lg proteins, but the allergenicity of reindeer beta-Lg has not
商品
Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.
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