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抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
DE-U-10, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~55 kDa
物種活性
rat, rabbit, hamster, porcine, goat, bovine, chicken, toad, sheep, mouse, human
加強驗證
independent
Learn more about Antibody Enhanced Validation
濃度
~1.0 mg/mL
技術
immunoblotting: 0.5-1 μg/mL using whole extract of mouse myoblast C2C12 cells
immunofluorescence: 2-5 μg/mL using mouse myoblast C2C12 cells
immunohistochemistry: 2.5-5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Appendix
microarray: suitable
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... DES(1674)
mouse ... Des(13346)
rat ... Des(64362)
一般說明
Anti-Desmin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma DE-U-10 produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/C mouse. Desmin, a major intermediate filament protein in skeletal, cardiac and smooth muscle cells. It is predominantly localised to filamentous extrasarcomeric cytoskeleton, which links neighbouring myofibrils and connects the myofibrillar apparatus with the subsarcolemmal cytoskeleton, myonuclei and mitochondria.
免疫原
Desmin purified from pig stomach
應用
Anti-Desmin antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
- microarray
生化／生理作用
Mutations is the desmin gene (known as desminopathy or DRM) are associated with several human diseases such as atrophy and facial muscle weakness, cardiomyopathy, cardiac arrhythmias and restrictive heart failure and are characterized by intracellular desmin aggregates. Anti-Desmin antibodies can be implemented for cancer research and diagnostics since elevated levels of desmin characterize several types of muscle tissue tumors, such as leiomyomas and rhabdomyosarcomas. The antibody may also be used for meat research measurements.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
K R Sultan et al.
American journal of physiology. Cell physiology, 280(2), C239-C247 (2001-02-24)
The present study investigates the role of two major proteolytic systems in transforming rabbit and rat muscles. The fast-to-slow transformation of rabbit muscle by chronic low-frequency stimulation (CLFS) induces fast-to-slow transitions of intact, mature fibers and replacement of degenerating fibers
The physiological role of cardiac cytoskeleton and its alterations in heart failure
Sequeira V, et al.
Biochimica et Biophysica Acta - Biomembranes, 1838(2), 700-722 (2014)
Vasco Sequeira et al.
Biochimica et biophysica acta, 1838(2), 700-722 (2013-07-19)
Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid generation of force and movement central to the work generated by the heart. During each heart beat cardiac muscle cells perceive and experience changes in length and load
Tumor markers: An overview
Babu GS, et al.
Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 4(2), 87-87 (2012)
Claudia Kalbe et al.
Histochemistry and cell biology, 127(1), 95-107 (2006-08-10)
Recent research suggests that estrogen receptors (ERs) are of significance in skeletal muscle function. The aim of the present study was to investigate, whether ERalpha and ERbeta are expressed in different porcine skeletal muscles and in satellite cells derived from
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