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生物源
rat
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
DECMA-1, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~120 kDa
物種活性
dog, mouse
濃度
~1 mg/mL
技術
immunoblotting: 0.5-1 μg/mL using whole extract of MDCK cells.
immunofluorescence: 5-10 μg/mL using MDCK cells
immunoprecipitation (IP): suitable
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Cdh1(12550)
一般說明
Monoclonal Anti-Uvomorulin/E-Cadherin (rat IgG1 isotype) is derived from the DECMA-1 hybridoma produced by the fusion of rat myeloma cells and splenocytes from an immunized Lou rat. Uvomorulin/E-Cadherin (Epithelial cadherin), also known as CDH1, CAM 120/80, L-CAM (Cell-Adhesion Molecule) or CD324, is a member of the cadherin transmembrane glycoproteins superfamily. It is characterized with a highly conserved cytoplasmic tail.
免疫原
Mouse embryonal carcinoma cell line PCC4 Aza RI
應用
Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat has been used in various immunochemical techniques including immunoblotting, immunoprecipitation, immunohistochemical staining and immunofluorescent staining.
生化／生理作用
Cadherins contribute to epithelial cell behavior and tissue morphogenesis/remodeling by facilitating cell-cell adhesion. Monoclonal Anti-Uvomorulin/E-Cadherin can be used for studies of embryonal development, cell-cell interaction of cells grown in culture, and localization of E-Cadherin. In addition, it is commonly used as an E-cadherin inhibitor/blocking antibody in a study of embryonic stem cells (EMS).
E-cadherin is a calcium-dependent glycoprotein. It is responsible for the homogeneous attachment between cells. It suppresses malignant transformation of tumors. Additionally, it also regulates cellular invasion and metastasis.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yan Zhang et al.
Molecular medicine reports, 12(3), 3393-3399 (2015-05-16)
The aim of the present study was to investigate the expression and clinical significance of hypoxia-inducible factor 1α (HIF-1α), Snail and E-cadherin in ovarian cancer. The expression levels were assessed in a number of ovarian cancer cell lines and ovarian
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
Hartsock A and Nelson WJ
Biochimica et Biophysica Acta - Biomembranes, 1778(3), 660-669 (2008)
Repetto O., et al.,
BioMed Research International, 2014, 408047-408047 (2014)
Cadherin-mediated cell-cell interactions in normal and cancer cells
Gloushankova NA, et al.
Tissue barriers, 5(3), e1356900-e1356900 (2017)
Eun Ju Lee et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 20(7), 1424-1433 (2012-03-29)
The beneficial effects of stem cells in clinical applications to date have been modest, and studies have reported that poor engraftment might be an important reason. As a strategy to overcome such a hurdle, we developed the spheroid three dimensional
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