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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~100 kDa
物種活性
human, mouse, rat
濃度
~1.0 mg/mL
技術
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells, and of mouse and rat liver microsomes.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HMGCR(3156)
一般說明
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein, encoded by the gene mapped to human chromosome 5q13.3-q14. HMGCR has a molecular mass of 97kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
免疫原
synthetic peptide corresponding to an internal sequence of human HMGCR, conjugated to KLH. The corresponding sequence is identical in human HMGCR isoform 2 and highly conserved in mouse (89% identity) and in rat (83% identity) HMGCR.
生化/生理作用
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as the rate-limiting step in cholesterol synthesis. Polymorphism in HMGCR results in late-onset Alzheimer′s disease. It induces the growth and migration of the cancer cells.
外觀
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila
PLoS ONE, 2 (2007)
HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells.
Gene, 587, 42-47 (2016)
Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13
Somatic Cell and Molecular Genetics, 15, 465-469 (1989)
Association of HMGCR polymorphism with late-onset Alzheimer's disease in Han Chinese
Oncotarget, 7(16), 22746-22751 (2016)
HMGCR positively regulated the growth and migration of glioblastoma cells.
Gene, 576, 22-27 (2016)
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