SAB4200370
Anti-PVRL4 antibody, Mouse monoclonal
clone N4.101.10, purified from hybridoma cell culture
别名:
Monoclonal Anti-Nectin-4/PVRL4 antibody produced in mouse, Monoclonal Anti-PVRL4 antibody produced in mouse, Anti-EDSS1, Anti-LNIR, Anti-Nectin-4, Anti-PRR4, Anti-PVRL4, Anti-Poliovirus receptor-related 4
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
N4.101.10, monoclonal
形狀
buffered aqueous solution
物種活性
human
濃度
~1.0 mg/mL
技術
flow cytometry: 5-10 μg/test using using 1x106 MDA-MB-231 cells
immunocytochemistry: 2.5-5 μg/mL using using MDA-MB-231 cells
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PVRL4(81607)
相关类别
一般說明
Monoclonal Anti-Nectin-4/PVRL4 (mouse IgG1 isotype) is derived from the hybridoma R2.525.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human nectin4-Fc recombinant protein. Nectin-4 belongs to the family of Nectins. It forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region in a Ca2+-independent manner. Nectin-4 is expressed in placenta, ductal breast carcinoma and lung adenocarcinomas. It is one of the plasma membrane components of adherens junctions.
免疫原
human Nectin4/Fc recombinant protein
應用
Monoclonal Anti-PVRL4 antibody produced in mouse has been used in immunocytochemistry and flow cytometry.
生化／生理作用
Nectin-4 is involved in cell adhesion through trans homophilic and heterophilic interactions. Mutations in this gene are associated with ectodermal dysplasia-syndactyly syndrome type 1.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nectin-4 is a new histological and serological tumor associated marker for breast cancer
Fabre-Lafay S, et al.
BMC Cancer, 7(1), 73-73 (2007)
Stephanie Fabre et al.
The Journal of biological chemistry, 277(30), 27006-27013 (2002-05-16)
Nectins form a family of integral molecules that belong to the immunoglobulin superfamily. Their ectodomain is made of three Ig-like domains (V, C, C). This family comprises at least five members, namely nectin1, -2, -3, -4, and poliovirus receptor (PVR)
Francesco Brancati et al.
American journal of human genetics, 87(2), 265-273 (2010-08-10)
Ectodermal dysplasias form a large disease family with more than 200 members. The combination of hair and tooth abnormalities, alopecia, and cutaneous syndactyly is characteristic of ectodermal dysplasia-syndactyly syndrome (EDSS). We used a homozygosity mapping approach to map the EDSS
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