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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~120 kDa
物種活性
human
加強驗證
recombinant expression
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.0 mg/mL
技術
western blot: 1-2 μg/mL using HEK293-T cells expressing human PGC-1α
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PPARGC1A(10891)
一般說明
PPARG coactivator 1 α (PPARGC1A), a master transcriptional coactivator is a 91kDa multifunctional regulatory factor, encoded by the gene mapped to human chromosome 4p15.1. The encoded protein is mainly expressed in heart, skeletal muscle and kidney.
應用
Anti-PGC-1α(N-terminal) antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
PPARG coactivator 1 α (PPARGC1α) integrates and regulates several metabolic pathways in response to external stimuli. PGC-1α regulates adaptive thermogenesis in brown adipose tissue and insulin signaling in skeletal muscle by activation of central metabolic and energy-related genes. It has a central role in the regulation of liver gluconeogenesis, β-oxidation of fatty acids and ketogenesis, by coactivation of key enzymes in the metabolic pathway, indicating that PGC-1α plays an important role as a global regulator of liver metabolism during fasting. PGC-1a is also a potent activator of mitochondrial biogenesis by coactivation of estrogen related receptor α(ERRα), nuclear respiratory factors (NRF)-1 and NRF-2. PGC-1a has been shown to suppress the generation of reactive oxygen species (ROS) and neurodegeneration by protecting neuronal cells from oxidative stress-mediated death. PGC-1α has been recently proposed to control muscle plasticity, to suppress broad inflammatory response and mediate the beneficial aspects of exercise.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
Mol. Neurodegener., 6, 32-32 (2011)
PGC-1alpha, glucose metabolism and type 2 diabetes mellitus
The Journal of Endocrinology, 229(3), 99-115 (2016)
PGC-1 coactivators in the control of energy metabolism
Acta biochimica et biophysica Sinica, 43(4), 248-248 (2011)
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
Cell, 127(2), 397-408 (2006)
The Journal of physiology, 592(12), 2535-2548 (2014-03-19)
Elevations of cardiomyocyte apoptosis and fibrotic deposition are major characteristics of the ageing heart. Resveratrol, a polyphenol in grapes and red wine, is known to improve insulin resistance and increase mitochondrial biogenesis through the SIRT1-PGC-1α signalling axis. Recent studies attempted
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