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生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
NX-38, monoclonal
形狀
buffered aqueous solution
分子量
antigen 80 kDa
物種活性
mouse, human, rat
包裝
antibody small pack of 25 μL
濃度
~1 mg/mL
技術
immunocytochemistry: suitable
western blot: 1-2 μg/mL using using rat brain S1 fraction extracts
同型
IgG2a
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NEXN(91624)
mouse ... Nexn(68810)
rat ... Nexn(246172)
一般說明
Monoclonal Anti-Nexilin (mouse IgG2a isotype) is derived from the hybridoma NX-38 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide conjugated to KLH. Nexilin is a filamentous actin-binding protein that localizes to focal contacts. Alternative splicing of the gene yields two different isoforms namely, b-nexilin and s-nexilin.
NEXN (nexilin), a cardiac Z-disc protein is made of 675 amino acids. It is present in the heart and skeletal muscle. NEXN is mapped to human chromosome 1p31.
特異性
Monoclonal Anti-Nexilin recognizes human, rat, and mouse nexilin.
應用
Anti-Nexilin antibody,Mouse monoclonal may be used in immunoblotting and immunocytochemistry.
生化／生理作用
NEXN (nexilin) plays an important role in protecting cardiac Z-discs from forces generated within the sarcomere. Mutations in NEXN results in hypertrophic cardiomyopathy.
Nexilin may be involved in cell adhesion and migration.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
儲存和穩定性
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A novel genetic variant in long non-coding RNA gene NEXN-AS1 is associated with risk of lung cancer.
Yuan H, et al.
Scientific Reports, 6, 34234-34234 (2016)
SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.
Hwang G, et al.
Development, dev-145607 (2017)
Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.
Wang H, et al.
American Journal of Human Genetics, 87(5), 687-693 (2010)
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