生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
分子量
antigen ~160 kDa
物種活性
human
包裝
antibody small pack of 25 μL
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1.5 mg/mL
技術
western blot: 0.8-1.6 μg/mL using extracts of HEK-293T cells overexpressing human AS160
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TBC1D4(9882)
一般說明
AS160 is a protein kinase B (Akt) substrate of 160 kDa, also known as TBC1D4. This gene is mapped to human chromosome 13q22.2 and encodes a Rab guanosine triphosphatase (GTPase)-activating protein (RabGAP). It has a number of insulin-regulatable protein kinase B (AKT) phosphomotifs. AS160 is expressed in many differentiated tissues such as adipocytes and skeletal muscles.
應用
Anti-AS160 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
生化／生理作用
AS160 (protein kinase B (Akt) substrate) is known to play an inhibitory role in the transport of glucose transporter 4 (GLUT4) vesicles. AS160 is associated with GLUT4 vesicles in basal states and dissociates in response to insulin. Reduced expression of AS160 in adipocytes has been shown to increase plasma membrane levels of GLUT4 in an insulin-dependent manner.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Insulin-induced effects on the subcellular localization of AKT1, AKT2 and AS160 in rat skeletal muscle
Zheng X and Cartee GD
Scientific Reports, 6(4), 39230-39230 (2016)
A method to identify serine kinase substrates Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain
Kane S, et al.
The Journal of biological chemistry, 277(25), 22115-22118 (2002)
Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells
Baus D, et al.
Cellular Signalling, 20(12), 2237-2246 (2008)
Cooperative actions of Tbc1d1 and AS160/Tbc1d4 in GLUT4-trafficking activities
Hatakeyama H, et al.
The Journal of Biological Chemistry, 294(4), 1161-1172 (2019)
Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease
Schwenk RW, et al.
Cardiovascular Research, 79(2), 249-258 (2008)
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