SAB4200024
Anti-Notch 1 antibody, Rat monoclonal
clone ICN 5B5, purified from hybridoma cell culture
别名:
Anti-Notch homolog 1, translocation-associated (Drosophila), Anti-TAN1, hN1, neurogenic locus notch homolog protein 1, Anti-Translocation-associated notch protein, Monoclonal Anti-Notch 1 antibody produced in rat
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About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
推荐产品
生物源
rat
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
ICN 5B5, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~120 kDa
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
western blot: 2-4 μg/mL using whole extract of human Jurkat cells and developing with a sensitive film
同型
IgG2b
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NOTCH1(4851)
一般說明
Monoclonal Anti-Notch 1 (rat IgG2b isotype) is derived from the hybridoma ICN 5B5 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant fusion protein corresponding to a fragment of human Notch 1 fusion protein. Notch receptor 1 (Notch1) gene is located on human chromosome 9q34.
應用
Monoclonal Anti-Notch 1 antibody produced in rat has been used in immunoblotting.
生化／生理作用
In chronic obstructive pulmonary disease, notch receptor 1 (Notch1) helps to modulate endothelial apoptosis via the extracellular signal-regulated kinase (ERK) pathway. Overexpression of Notch1 helps to guard endothelial cell from apoptosis. Knockdown of Notch1 results in the enhancement of apoptotic cells. Notch1 serves as a tumor suppressor gene in mammalian epidermis and is a determinant of keratinocyte differentiation. Notch signaling is believed to participate in several human neoplasms including T-cell acute lymphoblastic leukemia.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A
Karrman K, et al.
Journal of Hematology & Oncology, 8(1), 42-42 (2015)
Regulation of Notch1 gene expression by p53 in epithelial cells
Yugawa T, et al.
Molecular and Cellular Biology, 27(10), 3732-3742 (2007)
Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease
Zong D, et al.
American Journal of Physiology. Cell Physiology, 315(3), C330-C340 (2018)
Clinical and molecular characteristics of XPO1 mutations in patients with chronic lymphocytic leukemia
Jain P, et al.
American Journal of Hematology, 91(11), E478-E478 (2016)
Laura Asnaghi et al.
PloS one, 9(8), e105372-e105372 (2014-08-29)
The transcriptional response promoted by hypoxia-inducible factors has been associated with metastatic spread of uveal melanoma. We found expression of hypoxia-inducible factor 1α (HIF-1α) protein in well-vascularized tumor regions as well as in four cell lines grown in normoxia, thus
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