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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~32 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
immunoprecipitation (IP): 2.5-5 μg using GH3 cell lysates
western blot: 1-2 μg/mL using GH3 cell lysates
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... POU1F1(5449)
一般說明
POU1F1 is encoded by the gene mapped to human chromosome 3p11.2.
Pituitary-specific positive transcription factor 1 (POU1F1/PIT1) is a pituitary-specific transcription factor and is a member of the POU family of transcription factors.
特異性
Anti-POU1F1/PIT1 recognizes human POU1F1/PIT1.
應用
Anti-POU1F1/PIT1 antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
生化/生理作用
Pituitary-specific positive transcription factor 1 (POU1F1/PIT1) is responsible for pituitary development and hormone expression in mammals. It regulates mammalian development. POU1F1/PIT1 is required for the differentiation and proliferation of the anterior pituitary somatotrophs, lactotrophs and thyrotrophs cell lineages. Mutation in Pit-1 gene is associated with the syndrome of combined pituitary hormone deficiency (CPHD), a disease characterized by the lack of prolactin, growth hormone and thyroid stimulating hormone β. POU1F1/PIT1 regulates its target gene expression by binding to response elements on their promoter regions and recruitment of co-regulatory proteins, that alter histone acetylation and modify chromatin structures.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
儲存和穩定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
Best Practice & Research. Clinical Endocrinology & Metabolism, 25(1), 43-60 (2011)
Nature genetics, 44(4), 426-429 (2012-03-01)
We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P
Evolutionary and functional analysis of the key pluripotency factor Oct4 and its family proteins
Journal of Genetics and Genomics = Yi Chuan Xue Bao, 40(8), 399-412 (2013)
The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter
The Journal of Biological Chemistry, 275(40), 30977-30986 (2000)
Growth rate and carcass quality in pigs as related to genotype at loci POU1F1/RsaI (Pit1/RsaI) and GHRH/AluI
Animal Science Journal = Nihon Chikusan Gakkaiho, 21(3), 159-166 (2003)
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