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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
predicted mol wt 67 kDa
物種活性
mouse, rat, human
技術
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TOMM70A(9868)
一般說明
The Tom (translocase of the mitochondrial outer membrane) complex consists of two integral membrane import receptors, Tom20 and Tom70 (translocase of outer mitochondrial membrane 70) and a GIP (general import pore) complex. TOM70/ TOMM70A has 12 coding exons and spans about 37kb. It is abundantly expressed in human tissues and is located on human chromosome 3q13.1-q13.2. It belongs to the tetratricopeptide repeat (TPR) co-chaperone family. TOM70 has a dicarboxylate TPR clamp domain that can interact with molecular chaperones like Hsp70 (heat shock protein 70)/Hsc70 and/or Hsp90.
免疫原
TOM70 antibody was raised against a 17 amino acid peptide near the amino terminus of human TOM70.
生化／生理作用
TOM70/ TOMM70A (translocase of outer mitochondrial membrane 70) has the capability to identify preproteins with internal hydrophobic targeting sequences. It contributes in the transportation of several large hydrophobic matrix proteins. The import receptor Tom70 acts as a docking site for cytosolic multichaperone complexes.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
聯結
The action of this antibody can be blocked using blocking peptide SBP3500459.
外觀
Supplied in PBS with 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Human mitochondrial import receptor Tom70 functions as a monomer.
Fan AC, et al.
The Biochemical Journal, 429(3), 553-563 (2010)
Characterization of a human import component of the mitochondrial outer membrane, TOMM70A.
Edmonson AM, et al.
Cell communication & adhesion, 9(1), 15-27 (2002)
Anna C Y Fan et al.
The Journal of biological chemistry, 286(37), 32208-32219 (2011-07-21)
The mitochondrial import receptor Tom70 contains a tetratricopeptide repeat (TPR) clamp domain, which allows the receptor to interact with the molecular chaperones, Hsc70/Hsp70 and Hsp90. Preprotein recognition by Tom70, a critical step to initiate import, is dependent on these cytosolic
Sven Geisler et al.
Journal of cell science, 127(Pt 15), 3280-3293 (2014-06-08)
Depolarized mitochondria are degraded by mitophagy in a process that depends on the Parkinson's disease gene products PINK1 and Parkin. This is accompanied by ubiquitylation of several mitochondrial substrates. The roles of E2 ubiquitin-conjugating enzymes (UBE2) in mitophagy are poorly
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