推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
predicted mol wt 66 kDa
物種活性
rat, mouse, human
技術
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... IRAK3(11213)
一般說明
The IRAKM (interleukin-1 receptor-associated kinase-3) gene is mapped to human chromosome 12q14.3. This gene is predominantly expressed in monocytes and macrophages.
免疫原
IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M .
應用
Anti-IRAK-M antibody produced in rabbit has been used in Western blotting, immunoprecipitation and immunofluorescence.
生化／生理作用
The Irakm (interleukin-1 receptor-associated kinase-3) protein downregulates the toll like receptor (TLR)-signalling and influences the action of nuclear factor-κB (NF-κB). Increased IRAKM expression is observed in inflammatory bowel disease (IBD) and colorectal cancer. It is known to reduce the immune response against microorganism.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
聯結
The action of this antibody can be blocked using blocking peptide SBP3500193.
外觀
Supplied in PBS with 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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相關產品
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Implication of the toll-like receptor 4 pathway in the response to interferon-beta in multiple sclerosis
Bustamante MF, et al.
Annals of Neurology, 70(4), 634-645 (2011)
Enhanced mucosal defense and reduced tumor burden in mice with the compromised negative regulator IRAK-M
Rothschild DE, et al.
EBioMedicine, 15(1), 36-47 (2017)
Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis
Sode J, et al.
Pharmacogenomics, 18(1), 81-81 (2018)
Morris Nechama et al.
Nature communications, 9(1), 1603-1603 (2018-04-25)
Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines mRNAs, but the function of
The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation
Nechama M, et al.
Nature Communications, 9(1), 1603-1603 (2018)
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