推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
zebrafish, (Japanese Medaka)
技術
immunohistochemistry: suitable
western blot: 500-3000
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
zebrafish ... pcna(30678)
一般說明
Proliferating cell nuclear antigen (PCNA) is a ring-shaped homotrimer protein, that is located at the center of the faithful duplication of eukaryotic genomes. Since it encircles the DNA, PCNA is also known as a sliding clamp. This gene is mapped to human chromosome 20p12.3.
免疫原
Recombinant protein containing a sequence corresponding to a region within amino acids 31 and 222 of pcna according to NP_571479
應用
Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000, IHC-Wm: 1:50-1:500, Immunostaining: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Anti-PCNA antibody has been used in the detection of proliferating cells by immunofluorescence.
Anti-PCNA antibody has been used in the detection of proliferating cells by immunofluorescence.
生化／生理作用
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase′s processibility during elongation of the leading strand.
Proliferating cell nuclear antigen (PCNA) controls the production of the leading and lagging strands, which are required for the duplication of DNA. It acts as a cell cycle regulatory protein. This protein regulates apoptosis. PCNA is also involved in non-replicative DNA synthesis events.
Proliferating cell nuclear antigen (PCNA) controls the production of the leading and lagging strands, which are required for the duplication of DNA. It acts as a cell cycle regulatory protein. This protein regulates apoptosis. PCNA is also involved in non-replicative DNA synthesis events.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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訊號詞
Warning
危險聲明
危險分類
Aquatic Chronic 3 - Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Forging ahead through darkness: PCNA, still the principal conductor at the replication fork.
Katherine NC and George-Lucian M
Molecular Cell, 65(3), 380?392-380?392 (2017)
Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression.
Kei JNC, et al.
Neural Dev., 12(1), 12-12 (2017)
The prognostic value of PCNA expression in patients with osteosarcoma: A meta-analysis of 16 studies.
Wang X, et al.
Medicine, 96(41), e8254-e8254 (2017)
PCNA (proliferating cell nuclear antigen)
Stoimenov I and Helleday T
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 16(3) (2012)
Jeremy Ng Chi Kei et al.
Neural development, 12(1), 12-12 (2017-07-15)
Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural retina of zebrafish, Müller glia are the main stem cell source
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