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生物源
goat
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human
技術
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LRP4(4038)
一般說明
Low density lipoprotein receptor-related protein 4 (LRP4) is expressed on the surface of the postsynaptic membranes. It acts as a receptor for agrin. The protein belongs to the low-density lipoprotein receptor-related proteins (LRPs) family. The LRP4 gene is localized on human chromosome 11p11.2.
免疫原
Peptide with sequence CSNPSYRTSTQEVK , from the internal region of the protein sequence according to NP_002325.2.
生化／生理作用
LRP4 (Low density lipoprotein receptor-related protein 4) is a multifunctional protein which controls the extracellular cell signaling pathways including Wnt β-catenin signaling. It is highly essential for maintaining the bone mineral density. LRP4 binds to Dkk1 (dickkopf 1) and sclerostin to control the bone growth via Wnt and bone morphogenic protein (BMP) signaling pathways. Clinically, it is highly important for the development of osteoporosis. Mutation in the LRP4 gene causes an autosomal-recessive congenital disorder, Cenani-Lenz syndrome characterized with limb and kidney malformations.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Twenty bone mineral density loci identified by large-scale meta-analysis of genome-wide association studies.
Fernando R, et al.
Nature Genetics, 41(11), 1199-1206 (2009)
LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.
Ohkawara B, et al.
Human Molecular Genetics, 23(7), 1856-1868 (2014)
Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.
Hong Y C
PLoS ONE, 4(4) (2009)
LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.
Yun Li
American Journal of Human Genetics, 86(86) (2010)
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