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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
29 kDa
物種活性
bovine, rat, dog, mouse, human
濃度
0.5-1 mg/mL
技術
immunoblotting: suitable
immunohistochemistry: suitable
登錄號
NM_002592
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PCNA(5111)
一般說明
增殖细胞核抗原(PCNA)是一种核蛋白，在哺乳动物中广泛表达。它是一种环状同型三聚体蛋白，在胸腺、骨髓、胎肝以及少数小肠和结肠细胞中高水平表达。PCNA主要位于细胞核。PCNA基因是单拷贝基因，定位于人类染色体20p13。
免疫原
靶向人IGFBP7 C末端区域的合成肽
應用
抗PCNA抗体已用于：
- 免疫印迹(1:500) (1:1,000) (1:750)
- far-western蛋白相互作用分析(1:1000)
- 免疫组化(1?:?50) (1:1000)
- 增殖细胞核抗原(PCNA)overlay assay（蛋白铺覆检测）(1:1,000)
生化／生理作用
增殖细胞核抗原(PCNA)参与DNA复制和修复。它是一种聚合酶δ辅助因子。在冈崎片段成熟中起着重要作用。PCNA可作为慢性淋巴细胞白血病(CLL)的预后和诊断标志物。在乳腺和十二指肠癌中PCNA蛋白也有高表达。
序列
合成肽位于以下区域内： LNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEGS
外觀
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Xiaolan Ye et al.
Medicine, 99(16), e19755-e19755 (2020-04-22)
Although proliferating cell nuclear antigen (PCNA) plays an important role in tumor proliferation and its expression level is closely related to the biological activity of tumor cells, PCNA expression in non-small cell lung cancer (NSCLC) has been seldom reported. In
Amaia González-Magaña et al.
Biomolecules, 10(4) (2020-04-12)
: Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes. It also interacts with
Elsayed I Salim et al.
Asian Pacific journal of cancer prevention : APJCP, 17(3), 1023-1035 (2016-04-05)
The purpose of this study was to investigate the role of colon cancer stem cells (CSCs) during chemicallyinduced rat multi-step colon carcinogenesis with or without the treatment with a specific cyclooxygenase-2 inhibitor drug (celecoxib). Two experiments were performed, the first
Gang Li et al.
Journal of cellular physiology (2019-02-26)
Renal cell carcinoma (RCC) is a common urinary system cancer with high morbidity and mortality rate. Clear cell renal cell carcinoma (ccRCC) is a highly aggressive and common type of RCC. More and effective therapeutic targets are badly needed for
Weixin Hou et al.
Journal of inflammation research, 14, 7295-7313 (2022-01-08)
Acute-on-chronic liver failure (ACLF) is a critical disease with a high fatality rate. Immune dysfunction and inflammatory responses are key risk factors in ACLF. Pyroptosis is a form of programmed cell death characterized by the release of inflammatory cytokines, which
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