SAB1410944

Anti-PDK4 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• 别名: FLJ40832
• 分類程式碼代碼: 12352203
• NACRES: NA.43

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 46.5 kDa
• 物種活性: human
• 技術: immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI登錄號: NM_002612
• UniProt登錄號: Q16654
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PDK4(5166)

说明

一般說明

Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) is a mammalian mitochondrial serine kinase, encoded by the gene mapped to human chromosome 7q21.3. The encoded protein belongs to the PDK family. PDK4 transcripts are highly expressed in heart and skeletal muscle. It is also expressed at moderate levels in human brain, placenta, lung, liver, kidney and pancreas.

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. (provided by RefSeq)

免疫原

PDK4 (NP_002603.1, 1 a.a. ~ 411 a.a) full-length human protein.

Sequence
MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM

生化／生理作用

Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) catalyzes the phosphorylation of pyruvate dehydrogenase (PDH and also facilitates ATP-dependent inactivation of the PDH complex. Thus, it plays a vital role in glucose utilization and lipid metabolism. Elevated expressions of the protein leads to progressive small vessel loss in pulmonary arterial hypertension (PAH) and reduced endothelial-pericyte interactions. PDK4 is considered to be an emerging therapeutic target for type 2 diabetes.

外觀

Solution in phosphate buffered saline, pH 7.4

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable