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Merck
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Key Documents

SAB1401818

Sigma-Aldrich

Anti-WDR77 antibody produced in rabbit

whole antiserum, buffered aqueous solution

别名:

HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

whole antiserum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

技術

western blot: 1:500-1:1000

NCBI登錄號

NM_024102.2

UniProt登錄號

Q9BQA1

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... WDR77(79084)

一般說明

WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM

免疫原

WDR77 (NP_077007.1, 1 a.a. ~ 342 a.a) full-length human protein.

Sequence
MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE

生化／生理作用

WD repeat domain 77 (WDR77) associates with protein arginine methyltransferase 5 (PRMT5) in a methylosome complex and stimulates its histone methyltransferase activity. It also binds to androgen receptors and modulates its target genes in prostate epithelial cells and prostate cancer.

外觀

Clear solution

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儲存類別代碼

10 - Combustible liquids

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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访问文档库

Expression and function of androgen receptor coactivator p44/Mep50/WDR77 in ovarian cancer.
Ligr M
PLoS ONE, 6(10), e26250-e26250 (2011)
A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study.
Roshandel D
BMC Medical Genetics, 12, 19-19 (2011)
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.
Stopa N
Cellular and Molecular Life Sciences, 72(11), 2041-2059 (2015)
Subcellular localization of p44/WDR77 determines proliferation and differentiation of prostate epithelial cells.
Gao S and Wang Z
PLoS ONE, 7(11), e49173-e49173 (2012)

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