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Merck
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主要文件

SAB1401363

Sigma-Aldrich

Monoclonal Anti-SLC6A11 antibody produced in mouse

clone 2C3, purified immunoglobulin, buffered aqueous solution

别名:

GAT-3, GAT3

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

2C3, monoclonal

形狀

buffered aqueous solution

物種活性

human

技術

capture ELISA: suitable
western blot: 1-5 μg/mL

同型

IgG2aκ

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SLC6A11(6538)

一般說明

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11.[supplied by OMIM

免疫原

SLC6A11 (NP_055044.1, 164 a.a. ~ 225 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
TELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLR

外觀

Solution in phosphate buffered saline, pH 7.4

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Qiping Dong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(32), 6250-6261 (2020-07-04)
Rett syndrome (RTT) is a severe neurodevelopmental disease caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene. Although altered interneuron development and function are clearly demonstrated in RTT mice, a particular mode of inhibition, tonic inhibition, has not
Bradley M Roberts et al.
Nature communications, 11(1), 4958-4958 (2020-10-04)
Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be determined by plasma membrane GABA uptake transporters (GATs)

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