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生物源
rabbit
品質等級
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
147254 Da
物種活性
human
技術
flow cytometry: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... PTPRC(5788)
相关类别
一般說明
Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 is expressed on T-cells and is found in multiple isoforms. The extracellular domain of the protein is predicted to have an amino-terminal mucin-like segment, a cysteine-rich domain and three fibronectin type 3 domains. The gene encoding this protein is localized on human chromosome 1q31.3.
應用
ANTI-CD45(C-TERMINAL) antibody produced in rabbit has been used in Western blotting.
生化／生理作用
Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 acts as a protein tyrosine phosphatase in leucocyte signaling. It has a role in flow cytometric diagnostics in leukemia. By dephosphorylation of Src kinases, the protein acts as a regulator of antigen receptor signaling in T and B cells. As a negative regulator of janus kinases, CD45 inhibits cytokine receptor signaling.
外觀
Supplied in PBS with 0.09% (W/V) sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Initiation of T cell signaling by CD45 segregation at `close-contacts?
Veronica T, et al.
Nature Immunology (2016)
CD45RO+ Memory T Lymphocytes ? a Candidate Marker for TNM-Immunoscore in Squamous Non?Small Cell Lung Cancer1
Erna-Elise Paulsen, et al.
Neoplasia (2015)
High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
Gunnar Cario, et al.
Haematologica (2014)
Replication of association of the PTPRC gene with response to anti?tumor necrosis factor therapy in a large UK cohort*
Darren Plant, et al.
Arthritis & Rheumatology (Hoboken, N.J.) (2011)
Clinicoradiological characteristics, management and prognosis of primary myeloid sarcoma of the central nervous system: A report of four cases
Bao Yang, et al.
Oncology Letters (2017)
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