生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
24656 Da
物種活性
human
技術
immunohistochemistry: 1:50-1:100
western blot: 1:2000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CTLA4(1493)
一般說明
CTLA4 (cytotoxic T-lymphocyte associated protein 4), also known as IDDM12 or CD152 (cluster of differentiation), is a T cell receptor which belongs to the immunoglobulin (Ig) superfamily. It is expressed on the surface of T helper cells. This gene is localized to human chromosome 2q33. This protein is composed of a cytosolic domain, a transmembrane region and a V domain of 116 amino acids. Alternative splicing of IDDM12 results in membrane and soluble forms. The membrane form works as homodimers and the soluble isoforms work as monomers.
生化／生理作用
CTLA4 (cytotoxic T-lymphocyte associated protein 4) or insulin dependent diabetes mellitus 12 (IDDM12) is responsible for inhibiting T-cell proliferation and facilitates T cell apoptosis. This protein is expressed post-antigen presentation and thus, is involved in immune and autoimmune disorders. It is implicated in the pathogenesis of various T cell mediated autoimmune disorders.
外觀
Supplied in PBS with 0.09% (W/V) sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
从最新的版本中选择一种：
The B7-CD28 superfamily.
Sharpe AH and Freeman GJ
Nature Reviews: Immunology (2002)
The codon 17 polymorphism of the CTLA4 gene in type 1 diabetes mellitus in the Baghdad population
Najwa Sh, et al.
Journal of Back and Musculoskeletal Rehabilitation (2014)
Daniele Saverino et al.
PloS one, 9(11), e112509-e112509 (2014-11-11)
Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic liver disease frequently characterized by anti-mitochondrial autoantibodies (AMA). A minority of patients are AMA-negative. Cytotoxic-T-Lymphocyte-Antigen-4 (CTLA-4) is a surface molecule expressed on activated T-cells delivering a critical negative immunoregulatory signal. A
Sigrid Regauer et al.
Histology and histopathology, 29(8), 1017-1025 (2014-01-10)
Introduction. Lichen planus (LP) is a chronic cytokine-mediated disease of possible auto-immune etiology. 25% of men have anogenital manifestations. Erosive penile LP causes a scarring phimosis of the foreskin in uncircumcised men. Mast cells as potent immune modulators have been
Jonas Pick et al.
European journal of immunology, 44(7), 2139-2152 (2014-04-12)
Although CD8(+) T cells that produce IL-17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8(+) T cells. Here, we show that CTLA-4 enhances the frequency of IL-17 in
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