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生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~123 kDa
物種活性
human
技術
western blot: 1:500-1:2,000
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... GUCY2C(2984)
一般說明
The guanylate cyclase 2C (GUCY2C) gene is mapped to human chromosome 12p12. The gene codes for a transmembrane receptor guanylate cyclase C (GC-C) and is expressed in intestine.
免疫原
synthetic peptide corresponding to amino acids 981-995 of human GUCY2C
應用
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化／生理作用
Guanylate cyclase 2C (GUCY2C) converts guanosine-5′-triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), upon binding of its ligand guanylin and uroguanylin, which are paracrine hormones. GUCY2C functions as a tumor suppressor and hinders intestinal tumorigenesis by inhibiting the protein kinase B/AKT signaling pathway. Transmembrane receptor guanylate cyclase C (GC-C) regulates the secretion of chloride. Alteration in the gene expression leads to congenital sodium diarrhoea (CSD).
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C
Muller T, et al.
Gut, 65, 1306-1313 (2019)
The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.
Lin JE
Gastroenterology, 138, 241-254 (2010)
Sayaka Akieda-Asai et al.
American journal of physiology. Cell physiology, 317(6), C1239-C1246 (2019-09-26)
Recently, we showed that double-transgenic rats overexpressing guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), specifically in macrophages demonstrate an antiobesity phenotype and low-expression levels of proinflammatory cytokines in the mesenteric fat even when fed a high-fat
Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12.
Mann EA
Genomics, 34, 265-267 (1996)
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