推荐产品
化驗
≥98% (HPLC)
品質等級
形狀
powder
光學活性
[α]/D ≥+225°, c = 1 in H2O
顏色
white to tan
溶解度
H2O: ≥18 mg/mL
儲存溫度
2-8°C
SMILES 字串
CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O
InChI
1S/C8H11NO5S/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14/h5-6H,3H2,1-2H3,(H,11,12)/t5-,6+/m1/s1
InChI 密鑰
FKENQMMABCRJMK-RITPCOANSA-N
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一般說明
舒巴坦是一种半合成青霉素砜，来源于6-氨基青霉烷酸。这种β-内酰胺化合物的特征为具有一个 β-内酰胺环。
應用
舒巴坦可用作β-内酰胺酶抑制剂测试中的β-内酰胺酶抑制剂。 它也可用于评估其对极端耐药的鲍曼不动杆菌的抗菌药效学作用。舒巴坦可用于细胞信号转导研究。
生化／生理作用
舒巴坦为 β-内酰胺酶的不可逆抑制剂，可使β-内酰胺如青霉素和头孢菌素失活。它也可对拟杆菌和革兰氏阴性菌的某些染色体介导酶起作用。它具有有限的抗菌活性。 但是，舒巴坦与其它潜在抗生素的联合使用对多重耐药型鲍曼不动杆菌感染有治疗作用。
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Sarah M Drawz et al.
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Since the introduction of penicillin, beta-lactam antibiotics have been the antimicrobial agents of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened by bacterial beta-lactamases. beta-Lactamases are now responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.
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Krisztina M Papp-Wallace et al.
Antimicrobial agents and chemotherapy, 56(11), 5687-5692 (2012-08-22)
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Shu Xia et al.
PloS one, 9(7), e100707-e100707 (2014-07-02)
To investigate CTX-M genotypes among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) isolated from patients with community-onset and hospital-onset infections in China, their clonality and the distribution of CTX-M variants in different specimens of community-onset and hospital-onset infections. ESBL-EC isolates were collected
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