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Merck

S9666

Sigma-Aldrich

鞘氨醇-1-磷酸

≥95% (TLC), powder, lipid second messenger

别名:

D-赤式-鞘氨醇-1-磷酸, (2S,3[R,4E)-2-氨基-4-十八碳烯-1,3-二醇1-磷酸酯

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About This Item

经验公式(希尔记法):
C18H38NO5P
CAS号:
分子量:
379.47
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77

产品名称

鞘氨醇-1-磷酸, ≥95%, powder

品質等級

化驗

≥95%

形狀

powder

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O

InChI

1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1

InChI 密鑰

DUYSYHSSBDVJSM-KRWOKUGFSA-N

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生化/生理作用

可与S1P1 和S1P3 受体结合的脂质第二信使。调动细胞内Ca2+ 储备并降低细胞cAMP。激活磷脂酶D。S1P可刺激内皮细胞的迁移,但抑制其他细胞类型细胞的迁移。 诱导血管生成。

特點和優勢

该化合物在受体分类和信号转导手册中 溶血磷脂受体 页面中进行了详细介绍。想要浏览手册的其他页面, 请单击此处

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Kaiqi Sun et al.
Nature communications, 7, 12086-12086 (2016-07-16)
Sphingosine-1-phosphate (S1P) is a bioactive signalling lipid highly enriched in mature erythrocytes, with unknown functions pertaining to erythrocyte physiology. Here by employing nonbiased high-throughput metabolomic profiling, we show that erythrocyte S1P levels rapidly increase in 21 healthy lowland volunteers at
Roland Martin et al.
Current topics in microbiology and immunology, 378, 149-170 (2014-04-15)
The development of fingolimod, an unselective functional antagonist of the interactions between sphingosine 1 phosphate (S1P) and sphingosine 1 phosphate receptors (S1PRs), as the first oral therapy for multiple sclerosis (MS) has been a milestone. The parallel intensive research on
H Okamoto et al.
Molecular and cellular biology, 20(24), 9247-9261 (2000-11-30)
Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that induces a variety of biological responses in diverse cell types. Many, if not all, of these responses are mediated by members of the EDG (endothelial differentiation gene) family G protein-coupled receptors EDG1, EDG3
William S Szczepaniak et al.
Translational research : the journal of laboratory and clinical medicine, 152(5), 213-224 (2008-11-18)
S1P has been demonstrated to protect against the formation of lipopolysaccharide (LPS)-induced lung edema when administered concomitantly with LPS. In the current study, we sought to determine the effectiveness of S1P to attenuate lung injury in a translationally relevant canine
Gregory T Kunkel et al.
Nature reviews. Drug discovery, 12(9), 688-702 (2013-08-21)
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review

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