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生物源
microbial
synthetic
描述
form: solid or semisolid
化驗
≥97%
bp
150 °C/5 mmHg (lit.)
mp
28-30 (lit.)
溶解度
water: 50 mg/mL, clear, colorless
儲存溫度
2-8°C
SMILES 字串
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChI 密鑰
PFNFFQXMRSDOHW-UHFFFAOYSA-N
基因資訊
human ... GRIN2B(2904)
rat ... Grin2a(24409)
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一般說明
精胺是一种多胺,可用作自由基清除剂。它可调节基因表达、稳定染色质、以及防止DNA损伤。精胺可抑制内切核酸酶介导的DNA片段化。
應用
精胺已被用于:
- 作为肌醇1,4,5-三磷酸酯受体(IP3R)/葡萄糖调节蛋白75(Grp75)/电压依赖性阴离子通道1(VDAC1)/线粒体钙单向转运蛋白(MCU)的激动剂,以激活小鼠足细胞中的MCU
- 丝虫寄生虫的基因枪转染中
- 生产腺相关病毒(AAV)
生化/生理作用
多胺位点混合型 NMDA 谷氨酸受体激动剂/拮抗剂。在高浓度 (1mM) 下观察到神经保护作用,而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用;抑制神经元一氧化氮合成酶 (nNOS)。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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实验方案
HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide
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