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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
H2O: >5 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cl.Cl.CN(CCN(C)Cc1cn(-c2cccc(c2)C(F)(F)F)c3ccccc13)CC4=COc5cc(C)c(C)cc5C4=O
InChI
1S/C32H32F3N3O2.2ClH/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35;;/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3;2*1H
InChI 密鑰
GOZMBJCYMQQACI-UHFFFAOYSA-N
基因資訊
human ... TNF(7124)
mouse ... TNF(21926)
rat ... TNF(24835)
應用
SPD304可用于TNF-α介导的细胞信号传导研究。
SPD304已用于抑制背根神经节细胞元中的肿瘤坏死因子受体1（TNFR1）以及结肠上皮细胞系中的肿瘤坏死因子受体α。
生化／生理作用
SPD304是一种具有全新作用机制的TNF-a活性小分子抑制剂。它可干扰三聚体TNF-a亚基的接触表面上的蛋白-蛋白相互作用、置换三聚体单元之一、导致三聚体的解离以及受体TNFR1的活性丧失。SPD304可抑制TNFR1受体与TNF-a结合，其体外IC50为22μM，并在HeLa细胞中抑制TNF-a介导的IkB降解刺激，其IC50为4.6 μM。
TNF-α的三聚化对其生物活性至关重要。SPD304通过与甘氨酸122残基的相互作用而抑制三聚化。它还可通过类似的相互作用抑制核因子-κB配体（RANKL）的受体活化剂的活性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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Molly M He et al.
Science (New York, N.Y.), 310(5750), 1022-1025 (2005-11-15)
We have identified a small-molecule inhibitor of tumor necrosis factor alpha (TNF-alpha) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-alpha activity in biochemical and cell-based assays with median inhibitory concentrations of 22 and 4.6
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TNF-α (tumor necrosis factor-α) is initially synthesized as a transmembrane protein that is cleaved by TACE (TNF-α-converting enzyme) to release soluble TNF-α. The elevated level of TNF-α in the brain and circulation in heart failure (HF) suggests an increase in
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