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About This Item
经验公式（希尔记法）:
C19H18N2O3S
CAS号:
分子量:
354.42
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
yellow
mp
134-135.5 °C
溶解度
DMSO: 19 mg/mL
儲存溫度
−20°C
SMILES 字串
CCOc1cc(cc(CSc2ccccc2)c1O)\C=C(/C#N)C(N)=O
InChI
1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)/b14-8+
InChI 密鑰
YKLMGKWXBLSKPK-RIYZIHGNSA-N
生化／生理作用
Protein tyrosine kinase inhibitor (IC50 = 370 nM). Also inhibits HGF-induced MAP kinase activation in hepatocytes and inhibits phospholipase D activity in human neutrophils.
包裝
Light sensitive and packaged under nitrogen.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Y Kanda et al.
Biochemical and biophysical research communications, 199(3), 1447-1452 (1994-03-30)
Thyrotropin-releasing hormone (TRH) is a well-known regulatory factor of prolactin (PRL) secretion and synthesis in lactotrophs. Recently we have found that TRH stimulates early tyrosine phosphorylation of MAP kinase in GH3 cells. Then we investigated whether tyrosine phosphorylation in TRH
A Burke-Gaffney et al.
British journal of pharmacology, 119(6), 1149-1158 (1996-11-01)
1. Tumour necrosis factor-alpha (TNF alpha) increases the expression of the adhesion molecule intercellular adhesion molecule-1 (ICAM-1) on cultured endothelial and epithelial cells and modulation of this may be important in controlling inflammation. Activation of tyrosine kinase(s) is known to
K Takenaga
Invasion & metastasis, 16(2), 97-106 (1996-01-01)
Treatment of high-metastatic Lewis lung carcinoma A11 cells with sodium orthovanadate, a phosphotyrosine phosphatase inhibitor, resulted in a dose- and time-dependent suppression of cell spreading on various extracellular matrix components such as Matrigel, fibronectin, laminin and type IV collagen, while
H Miyamoto et al.
International journal of immunopharmacology, 17(5), 433-441 (1995-05-01)
It is well known that rat basophilic leukemia cells (RBL-2H3) express high-affinity IgE receptors (Fc epsilon RI) and that the aggregation of these receptors causes the release of chemical mediators. When RBL-2H3 cells are sensitized with IgE antibody and subsequently
M Ida et al.
Biochemical pharmacology, 51(8), 1061-1067 (1996-04-26)
Pervanadate mimics several distinct insulin effects, including stimulation of hexose uptake in the in vitro system, and reduces the blood glucose level in streptozotocin-treated diabetic rats. It has been proposed that pervanadate induces insulin-like effects mediated through autophosphorylation and activation
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