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Merck

S101

Sigma-Aldrich

(R)-(+)-SKF-38393 盐酸盐

≥98% (HPLC), solid

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About This Item

经验公式(希尔记法):
C16H17NO2 · HCl
CAS号:
分子量:
291.77
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

光學活性

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

儲存條件

desiccated

顏色

off-white to light tan

溶解度

0.1 M HCl: 1.2 mg/mL
ethanol: 3.4 mg/mL
H2O: 5 mg/mL
aqueous base: unstable

SMILES 字串

Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1

InChI 密鑰

YEWHJCLOUYPAOH-PFEQFJNWSA-N

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應用

(R)-(+)-SKF-38393盐酸盐已用作D1多巴胺受体激动剂,研究其对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导帕金森病猕猴睡眠模式的影响。

生化/生理作用

(R)-(+)-SKF-38393盐酸盐是一种D1多巴胺受体激动剂和(±)-SKF-38393的活性对映异构体。它可增强海马体神经元中百日咳毒素不敏感性和蛋白激酶A介导谷氨酸释放。SKF-38393是一种苯并氮杂卓衍生物,具有降低食欲的作用。

特點和優勢

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

注意

光敏感

重構

溶液可在4°C条件下储存数日。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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