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物種活性
human
技術
ELISA: suitable
assay range
inter-assay cv: <10%
intra-assay cv: <12%
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... JAK2(3717)
一般說明
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-JAK2. The JAK2 (Janus kinase 2) gene is mapped to human chromosome 9p24.1.
應用
请参考Protocol了解详情。
生化／生理作用
Janus kinase 2 (JAK2) mediates epithelial-mesenchymal transition in hepatocellular carcinoma. The JAK2/STAT3 signaling pathway is associated with tumor development in a number of cancer such as gastric cancer. Mutation in the JAK2 gene is known to activate JAK2 receptor action even in the absence of ligand, inducing cell proliferation and opposing apoptosis.
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
閃點（°F）
Not applicable
閃點（°C）
Not applicable
SIRT6 inhibits growth of gastric cancer by inhibiting JAK2/STAT3 pathway.
Zhou J, et al.
Oncology Reports, 38(2), 1059-1066 (2017)
The genetic basis of haematological cancers (2016)
CD 274 (PDL 1) and JAK 2 genomic amplifications in pulmonary squamous?cell and adenocarcinoma patients.
Clave S, et al.
Histopathology, 72(2), 259-269 (2018)
Norcantharidin inhibits IL-6-induced epithelial?mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cells.
Gao Y, et al.
Oncology Reports, 38(2), 1224-1232 (2017)
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