重組細胞
expressed in E. coli
品質等級
形狀
buffered aqueous glycerol solution
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... RALB(5899)
應用
Can be used as a control in immunoblotting and in protein binding assays.
生化／生理作用
Ral B (21 kDa, native), a member of the Ras-like GTP binding protein family, is a crucial link in intracellular signaling cascades.
Ral B has been implicated in invasion and metastasis of human cancer cells. Reports have shown that depletion of Ral B by siRNA results in significantly reduced migration rates of tumor cells, while constitutively active Ral B promoted migration.
其他說明
GST-tagged Ras-like fusion protein
外觀
Supplied as a solution in 50 mM Tris, pH 7.5, containing 150 mM sodium chloride, 10 mM magnesium chloride, 1 mM DTT, and 10% glycerol.
儲存類別代碼
10 - Combustible liquids
Gary Oxford et al.
Cancer research, 65(16), 7111-7120 (2005-08-17)
The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of
Y Takai et al.
Physiological reviews, 81(1), 153-208 (2001-01-12)
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families.
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