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Merck

PZ0393

Sigma-Aldrich

Oxamniquine

≥98% (HPLC)

别名:

(2-((isopropylamino)methyl)-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl)methanol, 1,2,3,4-Tetrahydro-2-[[(1-methylethyl)amino]methyl]-7-nitro-6-quinolinemethanol

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About This Item

经验公式(希尔记法):
C14H21N3O3
CAS号:
分子量:
279.33
MDL號碼:
分類程式碼代碼:
12352200

化驗

≥98% (HPLC)

形狀

powder

顏色

faint yellow to dark brown

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

room temp

InChI

1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3

InChI 密鑰

XCGYUJZMCCFSRP-UHFFFAOYSA-N

生化/生理作用

Oxamniquine is an anthelmintic agent with schistosomicidal activity against Schistosoma mansoni.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Gordana Panic et al.
Antimicrobial agents and chemotherapy, 61(12) (2017-10-04)
To date, there is only one drug in use, praziquantel, to treat more than 250 million people afflicted with schistosomiasis, a debilitating parasitic disease. The aryl hydantoin Ro 13-3978 is a promising drug candidate with in vivo activity superior to
Anastasia Rugel et al.
ACS medicinal chemistry letters, 9(10), 967-973 (2018-10-23)
Schistosomiasis is a major human parasitic disease afflicting more than 250 million people, historically treated with chemotherapies praziquantel or oxamniquine. Since oxamniquine is species-specific, killing Schistosoma mansoni but not other schistosome species (S. haematobium or S. japonicum) and evidence for
Lidiany da Paixão Siqueira et al.
Acta tropica, 176, 179-187 (2017-08-15)
Neglected tropical diseases (NTDs) affect millions of people in different geographic regions, especially the poorest and most vulnerable. Currently NTDs are prevalent in 149 countries, seventeen of these neglected tropical parasitic diseases are classified as endemic. One of the most

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