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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
predicted mol wt 42 kDa
物種活性
human, mouse, rat
技術
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... S1PR1(1901)
一般說明
S1P1 (sphingosine-1-phosphate receptor 1) is one of the transmembrane G protein coupled receptor. It is a member of the endothelial differentiation gene (EDG) family of receptors, hence it is also known as endothelial differentiation gene (EDG-1). It is located on chromosome 1p21.
免疫原
a 14 amino acid peptide near the carboxy-terminus of the human S1P1.
生化／生理作用
S1P1 (sphingosine-1-phosphate receptor 1) acts as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It participates in angiogenesis and lymphangiogenesis. It is considered as a pro-tumorigenic receptor, as it induces migration of cancer cell and invasion along with tumor neovascularization.
聯結
The action of this antibody can be blocked using blocking peptide SBP4809.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sphingosine-1-phosph ate receptor 2
Adada M,et al.
FEBS Journal (2013)
S1PR1 mediates anti?apoptotic/pro?proliferative processes in human acute myeloid leukemia cells
Xu XQ, et al.
Molecular Medicine Reports, 14(4), 3369-3375 (2016)
Qi Lin et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(10), 9743-9750 (2014-06-29)
There are currently no accurate predictive markers of metachronous liver metastasis from colorectal cancer. Recent studies demonstrated that the expression patterns of sphingosine-1-phosphate receptor 1 (S1PR1) are altered in several tumors, but in colorectal cancer, the patterns remain unknown. Our
Babita Rahar et al.
High altitude medicine & biology, 20(1), 78-88 (2019-03-21)
High altitude exposure alters biochemical, metabolic, and physiological features of heart and skeletal muscles, and hence has pathological consequences in these tissues. Central to these hypoxia-associated biochemical/metabolic shuffling are energy deficit accumulation of free radicals and ensuing oxidative damage in
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