推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
predicted mol wt 55 kDa
物種活性
mouse, human
技術
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... XIAP(331)
一般說明
XIAP (X-linked inhibitor of apoptosis protein) belongs to the inhibitor of apoptosis (IAP) family. It is located on chromosome Xq25.
免疫原
a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP.
應用
Anti-XIAP has been used in immunohistochemistry {16,17}.
生化／生理作用
XIAP (X-linked inhibitor of apoptosis protein) modulates several cellular processes like TGF-β (transforming growth factor β) signaling, NF-κB (nuclear factor-κB) pathway, autophagy and inflammatory responses. XIAP mutations are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2).
聯結
The action of this antibody can be blocked using blocking peptide SBP3331.
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress
Riley A, et al.
Nucleic Acids Research, 38(14), 4665-4674 (2010)
Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury
Reigada D, et al.
Neuroscience, 300, 404-417 (2015)
Chao Chen et al.
Oncology letters, 15(1), 821-832 (2018-02-07)
The X-linked inhibitor of apoptosis protein (XIAP) is the best characterized member of the IAP family and is a potent inhibitor of the caspase/apoptosis pathway. It has also been revealed that XIAP has additional biological functions that rely on its
Zhuan Zhou et al.
EBioMedicine, 15, 48-61 (2017-01-04)
The emerging regulatory role of deubiquitinases (DUBs) has been implicated in various fundamental processes and pathogenesis. To determine the pivotal role that DUBs play in mediating tumorigenesis, we have performed a non-biased screen of 67 human DUBs based on a
Yiping Zhang et al.
OncoTargets and therapy, 11, 8751-8759 (2018-12-26)
Carboplatin is a first-line treatment for ovarian cancer. However, most patients develop resistance and undergo disease recurrence. This study aims to explore the relationship between the expression of X-linked inhibitor of apoptosis protein (XIAP) and carboplatin sensitivity in ovarian cancer.
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