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Merck
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主要文件

PRS2221

Sigma-Aldrich

Anti-BAFF antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-BLyS, Anti-Tall, Anti-Thank, Anti-Tumor necrosis factor (ligand) superfamily, member 13b

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

predicted mol wt 31 kDa

物種活性

human, rat, mouse

技術

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

一般說明

B-lymphocyte activating factor (BAFF/TNFSF13B) is a cytokine that belongs to the TNF (tumor necrosis factor) superfamily. BAFF is located on human chromosome 13q33.

免疫原

a peptide corresponding to amino acids near the carboxy-terminus of human BAFF.

生化/生理作用

B cell activating factor (BAFF) participates in B cell and T cell mediated immunity. It plays a key role in the survival and differentiation of B cells. Mutations in BAFF regulates the levels of antibody. BAFF also participates in enhancing the responses of IL-6 (interlukin-6) and TNF-α (tumor necrosis factor alpha), that helps hepatocytes in the production of acute-phase protein.

聯結

The action of this antibody can be blocked using blocking peptide SBP2221.

外觀

Solution in phosphate buffered saline containing 0.02% sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system?related LIG4, TNFSF13B and IRS2 genes.
Acevedo N, et al.
Clinical and Experimental Immunology, 157(2), 282-290 (2009)
Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case?control study.
Eilertsen G?, et al.
Rheumatology (Basel), 50(12), 2197-2205 (2011)
B cell-activating factor regulates the survival of B lymphocytes infected with human cytomegalovirus.
Xu H, et al.
Immunology Letters, 187, 1-6 (2017)
Association of genetic variation in B-cell activating factor with chronic hepatitis B virus infection.
Han Q, et al.
Immunology Letters, 188, 53-58 (2017)
Polymorphism in the 5′ regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome.
Nossent JC, et al.
Rheumatology (Basel), 47(9), 1311-1316 (2008)

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