推荐产品
生物源
rabbit
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
等級
Powered by Bethyl Laboratories, Inc.
物種活性
human
技術
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000
登錄號
NP_005643.1
運輸包裝
wet ice
儲存溫度
2-8°C
基因資訊
rabbit ... TRF2(7014)
一般說明
The telomeric repeat binding factor 2 (TRF2 ) gene codes for a component of shelterin. The encoded protein is dimer containing four domains : B domain at the N-terminal, the TRF homology domain, the hinge domain and the MYB/SANT (proto-oncogene, transcription factor telobox) domain at C-terminal.
免疫原
The epitope recognized by PLA0144 maps to a region between residue 375 and 425 of human Telomeric Repeat Binding Factor 2 using the numbering given in entry NP_005643.1 (GeneID 7014).
生化／生理作用
TRF2 (telomeric repeat binding factor 2) is responsible for telomere stability by the insertion of the 3′ overhang. TRF2 offers protection to DNA from being wrongly recognized by the DNA damage repair systems. Loss of TRF2 function induces DNA repair system resulting in apoptosis by causing cell cycle arrest. Upregulation of the TRF2 gene is observed in cancer and thus concluded to contribute to tumor progression.
外觀
Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide
其他說明
Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that localizes at chromosome ends during all phases of the cell cycle and binds directly to TTAGGG repeats. TRF2 functions to protect telomeres as being perceived as sites of DNA damage. TRF2 interacts with several proteins at telomeres, such as Rap1, Mre11, Rad50, and NBS1.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2.
Wu M, et al.
Scientific Reports, 6, 36045-36045 (2016)
Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma.
Benhamou Y, et al.
Oncotarget, 7(28), 44236-44236 (2016)
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2.
Picco V, et al.
Oncotarget, 7(29), 46615-46615 (2016)
Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters.
Chen W, et al.
BioMed Research International, 2017, 9764752-9764752 (2017)
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