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P7340

(±)-苏-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇盐酸盐

Name: (±)-<I>苏</I>-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇 盐酸盐
Brand: SIGMA

别名:

(±)-苏-PDMP 盐酸盐, PDMP 盐酸盐

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About This Item

经验公式（希尔记法）:

C₂₃H₃₈N₂O₃·HCl

CAS号:

80938-69-8

分子量:

427.02

MDL號碼:

MFCD00236490

分類程式碼代碼:

12352200

PubChem物質ID:

24278649

NACRES:

NA.77

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C0283

L -肉碱盐酸盐

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M1177

Myriocin from Mycelia sterilia

生物源

synthetic (organic)

品質等級

100

化驗

≥98% (TLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

Cl.CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2

InChI

1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1

InChI 密鑰

HVJHJOYQTSEKPK-BLDCTAJRSA-N

生化／生理作用

葡萄糖神经酰胺合成酶抑制剂；阻止由神经酰胺形成葡萄糖基神经酰胺。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells.

J Inokuchi et al.

Journal of cellular physiology, 141(3), 573-583 (1989-12-01)

Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the levels of GlcCer and lactosylceramide (LacCer). The content of ganglioside GM3 was little affected, but the ability to bind a

Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.

Jorge F Haller et al.

Journal of lipid research, 55(3), 493-503 (2013-12-03)

ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid

Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells.

A A Weber et al.

British journal of pharmacology, 123(5), 906-910 (1998-04-16)

1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC)

Radin, et al.

Journal of Lipid Research, 26, 183-213 (1993)

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