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Merck
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Key Documents

P5498

Sigma-Aldrich

抗 Pro-NGF 兔抗

affinity isolated antibody, lyophilized powder

别名:

抗 促神经生长因子

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

lyophilized powder

物種活性

mouse, rat, human

技術

immunohistochemistry: suitable
western blot: 1:200-1:500

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NGFR(4804)
mouse ... Ngfr(18053)
rat ... Ngfr(24596)

特異性

pro-BDNF、pro-NT-3 或成熟的 NGF 不会发生交叉反应。

免疫原

对应于大鼠 NGF(前体)84-104 氨基酸残基的肽。该序列在小鼠中相同,在人中 16/21 个残基相同。

外觀

采用 pH 7.4 的磷酸盐缓冲盐水、1%BSA 和0.1% 叠氮化钠冻干而成

準備報告

用 0.2 mL 去离子水复溶冻干瓶。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Dermal - Aquatic Chronic 3

儲存類別代碼

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Comparison of nerve growth factor receptor binding models using heterodimeric muteins
Mehta HM et al
Journal of Neuroscience Research, doi: 10-doi: 10 (2012)
M Fahnestock et al.
Molecular and cellular neurosciences, 18(2), 210-220 (2001-08-25)
Nerve growth factor (NGF) is important for regulation, differentiation, and survival of peripheral and central nervous system neurons, including basal forebrain cholinergic neurons (BFCN) which degenerate in Alzheimer's disease (AD). Mature NGF protein is processed from a larger precursor, proNGF.
Death of injured neurons caused by the precursor of nerve growth factor.
Y-A Barde
Proceedings of the National Academy of Sciences of the United States of America, 101(16), 5703-5704 (2004-04-14)
Bai Lu
Neuron, 39(5), 735-738 (2003-09-02)
Neurotrophins are synthesized first as precursors, followed by maturation through proteolytic removal of the "pro" region. Since pro- and mature neurotrophins elicit opposite functional effects by differential interactions with Trks and p75 receptors, extracellular cleavage represents a new way to
Elahe Karimi et al.
Drug design, development and therapy, 13, 2513-2532 (2019-08-24)
Nowadays, the drug delivery system is important in the treatment of diseases. A polymeric nanoparticle modified by oleic acid (NPMO) as a Thymol (Thy) drug release system was synthesized from Thymbra spicata and its neurotrophic and angiogenic effects on rat's

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