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Merck

P1138

Sigma-Aldrich

1,2-二硬脂酰--甘油基-3-磷酸胆碱

≥99%

别名:

PC, 3- sn -磷脂酰胆碱,1,2-二硬脂酰, L-α-磷脂酰胆碱,二硬脂酰, L-β,γ-二硬脂酰-α-卵磷脂, DSPC, PC(18:0/18:0)

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About This Item

经验公式(希尔记法):
C44H88NO8P
CAS号:
分子量:
790.15
Beilstein:
3923978
EC號碼:
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25

生物源

semisynthetic

品質等級

化驗

≥99%

形狀

powder

官能基

phospholipid

脂質類型

phosphoglycerides

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI 密鑰

NRJAVPSFFCBXDT-HUESYALOSA-N

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一般說明

通过单一水合步骤形成负载有所选分子的无热原的,成分明确的脂质体。

應用


  • 金刚烷胺与相分离脂质膜的相互作用研究。:该研究探讨了金刚烷胺与相分离脂质膜之间的相互作用,深入了解了1,2-二硬脂酰-sn-甘油-3-磷酸胆碱在膜结构和功能中的作用(Kinnun et al., 2024)。

  • 采用微流控涂层技术设计电荷转换脂质纳米颗粒。:该研究使用1,2-二硬脂酰-sn-甘油-3-磷酸胆碱设计了具有电荷转换能力的脂质纳米颗粒,优化了药物递送系统(Zöller et al., 2024)。

  • 主动和被动包封法将蛋白质装载到脂质体中的研究和比较。:该研究比较了使用1,2-二硬脂酰-sn-甘油-3-磷酸胆碱将蛋白质包封到脂质体中的方法,推动了药物递送技术的发展(Pisani et al., 2023)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Sweta Modi et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 330-339 (2012-07-18)
Nanoparticulate drug carriers such as liposomal drug delivery systems are of considerable interest in cancer therapy because of their ability to passively accumulate in solid tumors. For liposomes to have practical utility for antitumor therapy in patients, however, optimization of
Antonella Accardo et al.
International journal of nanomedicine, 7, 2007-2017 (2012-05-24)
Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This study addresses novel liposome composition approaches to specifically target tissues overexpressing bombesin (BN)
Pan Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(2), 349-354 (2012-07-18)
Ultrasound targeted microbubble destruction (UTMD) was one of the most promising strategies to enhance drug delivery in cancer therapy. Microbubbles (MBs) serve as a vehicle to carry anti-tumor drugs and locally release them when exposed to therapeutic ultrasound, resulting in
Peter J Kueffer et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6512-6517 (2013-03-29)
The application of boron neutron capture therapy (BNCT) following liposomal delivery of a (10)B-enriched polyhedral borane and a carborane against mouse mammary adenocarcinoma solid tumors was investigated. Unilamellar liposomes with a mean diameter of 134 nm or less, composed of
Saumyabrata Mazumder et al.
PLoS neglected tropical diseases, 5(12), e1429-e1429 (2011-12-30)
Vaccines that activate strong specific Th1-predominant immune responses are critically needed for many intracellular pathogens, including Leishmania. The requirement for sustained and efficient vaccination against leishmaniasis is to formulate the best combination of immunopotentiating adjuvant with the stable antigen (Ag)

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