P0106

Pefloxacin 甲磺酸酯 二水合物

• 别名: 3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate, Pefloxacine monomethanesulfonate dihydrate, Pefloxacinium methanesulfonate dihydrate
• 线性分子式: C₁₇H₂₀FN₃O₃ • CH₄O₃S • 2H₂O
• CAS号: 149676-40-4
• 分子量: 465.49
• EC號碼: 274-613-9
• MDL號碼: MFCD01685696
• 分類程式碼代碼: 51101500
• PubChem物質ID: 329820015

属性

• 形狀: powder
• 品質等級: 100
• 溶解度: H₂O: 50 mg/mL
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: DNA synthesis | interferes; enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
• InChI: 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
• InChI 密鑰: LEULAXMUNMRLPW-UHFFFAOYSA-N

说明

一般說明

Chemical structure: fluoroquinolone

應用

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.

生化／生理作用

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P305 + P351 + P338
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves