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Merck

P0081

Sigma-Aldrich

Monoclonal Anti-PMP22 antibody produced in mouse

~1.0 mg/mL, clone CF1, purified immunoglobulin, buffered aqueous solution

别名:

Anti-CMT1A, Anti-Charcot-Marie-Tooth neuropathy 1A, Anti-GAS3, Anti-Growth arrest-specific 3, Anti-HNPP, Anti-Peripheral myelin protein 22

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About This Item

分類程式碼代碼:
12352203

生物源

mouse

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

CF1, monoclonal

形狀

buffered aqueous solution

分子量

antigen ~22 kDa

物種活性

human, monkey

包裝

antibody small pack of 25 μL

濃度

~1.0 mg/mL

技術

immunocytochemistry: suitable
immunohistochemistry: 2.5-5 μg/mL using human spinal cord tissue sections.
indirect ELISA: suitable
western blot: suitable

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... PMP22(5376)

一般說明

Peripheral myelin protein 22 (PMP22), also known as growth arrest-specific protein 3 (GAS-3), is a tetraspan glycoprotein. It is highly expressed in myelin-forming Schwann cells of peripheral nerves. The gene encoding it is localized on human chromosome 17p12–13.

免疫原

peptide corresponding to the second extracellular domain of human PMP22 (amino acids 120-133).

生化/生理作用

Peripheral myelin protein 22 (PMP22) plays a vital role in myelination during peripheral nerve development. It also has a role in cell-cell interactions, cell proliferation, maintenance of axons and the determination of myelin thickness and stability. Aberrations or mutations in the PMP22 gene lead to heritable demyelinating peripheral neuropathies, such as Charcot-Marie-tooth disease type IA (CMT1A) and Dejerine-Sottas syndrome. Overexpression of PMP22 might contribute to the development of chronic myeloid leukemia (CML).

外觀

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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在文件库中查找您最近购买产品的文档。

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Knockdown of Peripheral Myelin Protein 22 Inhibits the Progression of Chronic Myeloid Leukemia.
Liu H
Oncology Research (2014)
Isolation and mapping to 17p12-13 of the human homologous of the murine growth arrest specific Gas-3 gene.
Martinotti A
Human Molecular Genetics (1992)
Many facets of the peripheral myelin protein PMP22 in myelination and disease.
Microscopy Research and Technique (1998)
Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia.
Notterpek L
Proceedings of the National Academy of Sciences of the USA (2001)
Norman A Gregson et al.
Journal of the peripheral nervous system : JPNS, 12(1), 2-10 (2007-03-22)
We produced a mouse monoclonal antibody using cDNA and peptide immunization against the putative second extra-cellular domain of human peripheral myelin protein 22 (PMP22). It reacted specifically with human PMP22 and not with other human myelin proteins and did not

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