所有图片(1)
About This Item
经验公式（希尔记法）:
C4H5NO5
CAS号:
分子量:
147.09
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
溶解度
deionized water: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
OC(=O)CNC(=O)C(O)=O
InChI
1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
InChI 密鑰
BIMZLRFONYSTPT-UHFFFAOYSA-N
生化／生理作用
N-草酰甘氨酸是 α-酮戊二酸依赖性酶的抑制剂，并且模仿初始步骤，但不引发羟基化过程。N-草酰甘氨酸已被用于抑制含有 Jumonji C 结构域的组蛋白赖氨酸去甲基化酶。
特點和優勢
该化合物收录于受体分类和信号转导手册的《谷氨酸/GABA合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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eLife, 9 (2020-03-21)
H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic silencing. Here, we reveal an inversion of this
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Cell reports, 33(5), 108341-108341 (2020-11-05)
Dysregulated gene expression is a common feature of cancer and may underlie some aspects of tumor progression, including tumor relapse. Here, we show that recurrent mammary tumors exhibit global changes in gene expression and histone modifications and acquire dependence on
Xiongwen Cao et al.
Cell reports, 30(12), 4152-4164 (2020-03-27)
Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown. Here, we perform a screening of a cDNA library
Tim J Wigle et al.
Journal of biomolecular screening, 20(6), 810-820 (2015-03-11)
Demethylation of histones by lysine demethylases (KDMs) plays a critical role in controlling gene transcription. Aberrant demethylation may play a causal role in diseases such as cancer. Despite the biological significance of these enzymes, there are limited assay technologies for
商品
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
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