O3251

催产素

• 别名: α-多巴胺, 催产激素
• 经验公式（希尔记法）: C₄₃H₆₆N₁₂O₁₂S₂
• CAS号: 50-56-6
• 分子量: 1007.19
• Beilstein: 3586108
• EC號碼: 200-048-4
• MDL號碼: MFCD00076731
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24897975
• NACRES: NA.32

属性

• 生物源: synthetic (organic)
• 品質等級: 200
• 無菌: non-sterile
• 化驗: ≥97% (HPLC)
• 形狀: lyophilized powder
• UniProt登錄號: P01178; P30559; P70536
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• InChI 密鑰: XNOPRXBHLZRZKH-DSZYJQQASA-N
• 基因資訊: human ... OXT(5020) , OXTR(5021) ; rat ... Oxtr(25342)

说明

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

一般說明

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

應用

Oxytocin has been used in experimental study to induce uterine contractions in rats. It has been used in comet assay to determine the number of cells with DNA damage.

生化／生理作用

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

刺激子宫收缩和哺乳；增加Na⁺ 排泄；刺激子宫肌层GTP酶和磷脂酶 C。

外觀

Supplied as a powder with a peptide content of ≥ 75%

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable