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生物源
human brain
品質等級
化驗
≥95% (SDS-PAGE)
形狀
buffered aqueous solution
比活性
≥10 units/mg protein
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... ENO2(2026)
一般說明
神经元特异性烯醇化酶(NSE)是糖酵解酶烯醇化酶的神经元形式，首先在脑组织提取物中发现。
應用
来自人脑的神经元特异性烯醇化酶已用于评估人羊膜间充质干细胞治疗局灶性脑缺血的研究。 它也被用于研究具有横纹肌样特征的鼻窦畸胎癌肉瘤。
生化／生理作用
神经元特异性烯醇化酶(NSE)在所有神经元细胞类型中表达，其表达标志着突触功能的获得。 急性神经元损伤后，神经元细胞体中的NSE水平升高。 血清和脑脊液中NSE水平的升高已被用作损伤和神经元细胞死亡的标志物。 源自许多细胞类型的肿瘤，包括大多数神经元和神经内分泌肿瘤，都表达NSE。
神经元特异性烯醇化酶促进神经元的存活，并可以通过以钙依赖性方式与神经元结合来提供神经保护作用。
單位定義
25°C，pH 6.8时，1个单位每分钟形成1.0μ摩尔磷酸（烯醇）丙酮酸盐
外觀
溶液，溶于100 mM Tris-HCl、5 mM MgSO4、250 mM KCl，pH 5.0-5.2
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Transplantation of human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia
Li, F., et al.
Molecular Medicine, 6, 625-630 (2012)
Neuron-specific enolase is produced by neuroendocrine tumours
Tapia, F., et al.
Lancet, 317, 808-811 (1981)
T Hattori et al.
Neuroscience research, 21(3), 191-198 (1995-01-01)
We previously reported that the gamma gamma-isozyme of enolase, NSE), one of the glycolytic enzymes, promoted the survival of embryonic rat neocortical neurons in culture, but alpha alpha-isozyme (non-neuronal enolase) had no effect. In the present study, the neurotrophic effects
Jo-Heon Kim et al.
Pathology international, 61(12), 762-767 (2011-12-01)
Sinonasal teratocarcinosarcoma (SNTCS) is a very rare tumor developed in the nasal cavity and paranasal sinuses. The rhabdoid phenotype represents an aggressive biological behavior, but the rhabdoid feature has hitherto not been reported in cases of SNTCS. A 46-year-old man
O A Iuneman et al.
Arkhiv patologii, 74(5), 23-26 (2013-01-25)
The paper gives the data of studying the cells belonging to neuroblast progeny in embryonic origin. Differentiation in these cells was studied by immunohistochemical assay using a number of neuronal markers. Expression of S-100, NCAM, and neuron-specific enolase was revealed
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