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Merck
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Key Documents

MSTUD0202

Sigma-Aldrich

MISSION® Synthetic microRNA Inhibitor, Mouse

mmu-miR-21a-5p

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.51

品質等級

產品線

MISSION®

形狀

solid

成熟序列

UAGCUUAUCAGACUGAUGUUGA

Sanger 成體/幼體登錄號

儲存溫度

−20°C

一般說明

Individual synthetic microRNA inhibitors were designed using a proprietary algorithm, which is based on the work of Haraguchi, T, et al. and in collaboration with Dr. Hideo Iba, University of Tokyo. This algorithm utilizes the tough decoy (TuD) design. miRNA are known to regulate gene expression in a variety of manners, including translational repression, mRNA cleavage and deadenylation.

The MISSION synthetic miRNA Inhibitors are small, double-stranded RNA molecules designed to inhibit a specific mature miRNA. The miRNA inhibitors were designed using the mature miRNA sequence information from miRBase and are 2′-O-methylated RNA duplexes with a miRNA binding site on each strand. Optimal miRNA inhibition is provided after transfection due to the robust secondary structure of the inhibitor.

  • Long lasting inhibition at very low dosage
  • Excellent resistance to cellular nucleases
  • Custom synthesis available for a variety of species

Two negative controls are available: Arabidopsis thaliana sequence (NCSTUD001) and Caenorhabditis elegans sequence (NCSTUD002)

其他說明

Based on miRBase V19

法律資訊

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazard

訊號詞

Warning

危險聲明

防範說明

危險分類

STOT RE 2 Inhalation

標靶器官

Respiratory Tract

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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