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用途
sufficient for 100 colorimetric tests
應用
cosmetics
food and beverages
檢測方法
colorimetric
相關疾病
neurological disorders; cancer
儲存溫度
−20°C
一般說明
谷氨酸是两种酸性蛋白原氨基酸之一，也是细胞代谢中的关键分子。由谷氨酸脱氢酶从谷氨酸中合成α-KG是TCA循环中关键的厌氧反应。在人体中，谷氨酸在氨基酸降解和处理过量或废氮中都起着重要作用。在哺乳动物神经系统中，谷氨酸是最丰富的兴奋性神经递质。它被认为与学习和记忆有关，也可能与肌萎缩侧索硬化、自闭症、某些形式的精神发育迟滞、以及阿尔茨海默症#8242;等疾病有关。谷氨酸存在于各种食品中，并已用作食品工业中的增味剂。
應用
谷氨酸测定试剂盒已用于测定大鼠蛛网膜下腔出血模型中脑脊液中谷氨酸的浓度。其还被用于确定肌萎缩侧索硬化患者脑脊液中细胞溶质的和分泌的谷氨酸浓度。
適合性
其适用于对各种样品中的谷氨酸浓度进行测定。
原則
谷氨酸浓度通过偶联酶测定法进行测定，其能够产生与样品中存在的谷氨酸盐成比例的比色（450nm）产物。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
Developing medications targeting glutamatergic dysfunction in autism: progress to date.
Fung L K and Antonio Y H
CNS Drugs, 29(6), 453-463 (2015)
Glutamate as a neurotransmitter in the healthy brain.
Zhou Y and Danbolt N C
Journal of Neural Transmission. General Section, 121(8), 799-817 (2014)
Leena S Knight et al.
Neurochemical research, 42(12), 3490-3503 (2017-09-18)
Betaine (N-trimethylglycine), a common osmolyte, has received attention because of the number of clinical reports associating betaine supplementation with improved cognition, neuroprotection and exercise physiology. However, tissue analyses report little accumulation of betaine in brain tissue despite the presence of
Glutamate, at the interface between amino acid and carbohydrate metabolism.
Brosnan J T.
The Journal of Nutrition, 130(4), 988S-990S (2000)
The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model.
Zhang Z, et al.
Experimental Neurology, 301, 13-25 (2018)
商品
Sigma-Aldrich presents an article about how proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metabolites away from mitochondrial oxidative phosphorylation, many tumor cells exhibit increased mitochondrial activity.
实验方案
Assay protocol for the colorimetric detection of Glutamate in biological samples using the Glutamate assay kit.
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