推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~86 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
immunoprecipitation (IP): 5-10 μg using HeLa human epitheloid carcinoma cell lysate
western blot (chemiluminescent): 0.5-1 μg/mL using extract of mouse and rat brain mitochondria
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MFN2(9927)
mouse ... Mfn2(170731)
rat ... Mfn2(64476)
一般說明
Anti-Mitofusin 2 is produced in rabbit using as immunogen a synthetic peptide corresponding to human mitofusin 2 with an N-terminal added cysteine, conjugated to KLH. Mitofusins (Mfn1 and Mfn2) form homotypic and heterotypic complexes for fusion in mitochondria.
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein.
免疫原
synthetic peptide corresponding to amino acid residues 557-576 of human mitofusin 2 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by one and two amino acids in rat and mouse mitofusin 2, respectively.
應用
Anti-Mitofusin 2 antibody has been used in immunoblotting. It may also be used in immunoprecipitation.
Anti-Mitofusin 2 antibody produced in rabbit has been used for Western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化／生理作用
MFN2 is essential for the maintenance of mitochondrial network and controls mitochondrial metabolism. Mfn2-dependent regulatory mechanism is disturbed in obesity by reduced Mfn2 expression. Mutations in MFN2 cause Charcot Marie-Tooth neuropathy type 2A, a neurological disorder that results from degeneration of axons in peripheral nerves.
Mitofusin-2 (MFN2) plays an important role as a mitochondrial fusion protein and participates in many cell processes. It is mainly involved in regulating metabolic processes in the mitochondria. MFN2 prevents the formation of reactive oxygen species and controls endoplasmic reticulum stress. Mutations in the gene encoding this protein have been linked to diabetes and obesity.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging
Joseph A M,et al.
Testing, 8(7), e69327-e69327 (2013)
Ashley J Smuder et al.
Free radical biology & medicine, 115, 179-190 (2017-12-05)
Mechanical ventilation (MV) results in the rapid development of ventilator-induced diaphragm dysfunction (VIDD). While the mechanisms responsible for VIDD are not fully understood, recent data reveal that prolonged MV activates autophagy in the diaphragm, which may occur as a result
Mfn2 is critical for brown adipose tissue thermogenic function
Boutant M,et al.
The Embo Journal, 36(11), 1543-1558 (2017)
Kuang-Hueih Chen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(1), 382-394 (2013-10-02)
It has been reported that Mitofusin2 (Mfn2) inhibits cell proliferation when overexpressed. We wanted to study the role of endogenous Mfn2 in cell proliferation, along with the structural features of Mfn2 that influence its mitochondrial localization and control of cell
A-M Joseph et al.
Biogerontology, 15(5), 517-534 (2014-08-12)
Mitochondrial dysfunction in various tissues has been associated with numerous conditions including aging. In testes, aging induces atrophy and a decline in male reproductive function but the involvement of mitochondria is not clear. The purpose of this study was to
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