M2199

PMEG hydrate

≥98% (HPLC)

• 别名: 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate
• 经验公式（希尔记法）: C₈H₁₂N₅O₅P · xH₂O
• CAS号: 1255517-79-3
• 分子量: 289.19 (anhydrous basis)
• MDL號碼: MFCD19443863
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329817932
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to off-white
• 溶解度: DMSO: ≥5 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1
• InChI: 1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2
• InChI 密鑰: BDVQXHFCXJXVND-UHFFFAOYSA-N

说明

生化／生理作用

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3